The Delta State Polytechnic, Ozoro was established by Law enacted on January 1, 2002 during the administration of His Excellency Chief James Onanefe Ibori. The Polytechnic was established along with two other polytechnics, at Ogwashi-Uku and Otefe-Oghara, and a College of Physical Education, Mosogar (now College of Education, Mosogar).

At the inception, the three polytechnics and College of Physical Education were managed as the Delta State Higher Education Project (DSHEP) in partnership with the University of Westminster, London. This arrangement was designed to fast track the development of the institutions.